Biosurfactant potential and antiviral activity of multistrain probiotics

Kok, Tjie and Nyotohadi, Denny (2023) Biosurfactant potential and antiviral activity of multistrain probiotics. Heliyon, 10 (1). e22837. ISSN 2405-8440

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Abstract

The COVID-19 caused by the SARS-CoV-2 has become a great threat to humans. However, there is no recommendation for an effective and safe drug to treat the disease. The strategy developed in this study is to utilize biosurfactant potential activity of Lactobacillus spp. and Rhodopseudomonas palustris probiotics to prevent the virus from entering human body. The outer membrane of the virus is comprising of phospholipid compounds. Biosurfactants, are known to have detergent-like properties (able to dissolve lipids) that are safe for in vivo use. Thus, the biosurfactant potential activity of the multistrain probiotics extract is expected to be able to disrupt the phospholipid membrane, resulting in the inactivity of the virus to infect human body. The biosurfactant po- tential activity of the probiotics extract was evaluated using oil spreading, drop collapse, and emulsification methods. The virus infectivity was evaluated on the SARS-CoV-2 of delta variant as a virus model. The results indicated that the probiotics extract has biosurfactant potential ac- tivity, able to inhibit virus growth up to 99.9 % within 48 h in the prevention platform, and up to 99.6 % within 48 h in the treatment platform. Therefore, the multistrain probiotics extract was identified to have potential as a promising antiviral agent

Item Type:	Article
Uncontrolled Keywords:	Biosurfactant activity; Antiviral activity; Multistrain probiotics; SARS-CoV-2; Virus infectivity
Subjects:	T Technology > T Technology (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	Ester Sri W. 196039
Date Deposited:	16 Jan 2024 05:19
Last Modified:	05 Feb 2024 02:03
URI:	http://repository.ubaya.ac.id/id/eprint/45714

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