Meta-Analysis on the effectiveness of the Use of Prophylactic Antibiotics in Preventing Surgical Site Infection in Patients with Hernia Surgery

Wijono, Heru and Kristin, Febryza and Peerera, Beryl Bayanaka Agustha and Herawati, Fauna and Yulia, Rika (2023) Meta-Analysis on the effectiveness of the Use of Prophylactic Antibiotics in Preventing Surgical Site Infection in Patients with Hernia Surgery. In: Proceedings of the Conference on Natural Resources And Life Sciences 2022 (NRLS-BIO 2022), 24-25 August 2022, Surabaya, Indonesia (Online).

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Abstract

The administration of prophylactic antibiotics in hernia surgery patients is currently controversial, with varying opinions regarding their necessity. The European Hernia Society guideline does not recommend prophylactic antibiotics in patients with hernia surgery, while recent studies found that prophylactic antibiotics in hernia surgery patients can be given routinely and are effective in reducing surgical site infections. This study aims to determine the effectiveness of prophylactic antibiotics for preventing surgical site infection in patients with hernia surgery. This research is a systematic review using articles with a randomized controlled trial (RCT) research design using Indonesia and English language within the last 10-year of publication year. Twenty-four RCTs that met the inclusion and exclusion criteria were used to address the research problem. The results showed that a total of 207 patients experienced the incidence of surgical site infection in patients with hernia surgery, including 78 patients (4.5%) in the antibiotic group and 129 patients (7.88%) in the control. A significant difference was found between the antibiotic and the control groups in preventing surgical site infections, with a P-value < 0.0001 (OR = 0.56; 95% CI = 0.42–0.75). Conclusion: Surgical site infections are less likely to develop when a prophylactic antibiotic is administered to patients with hernia surgery.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	prophylactic antibiotics; surgical site infection; hernia surgery
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	30 Jan 2024 04:20
Last Modified:	30 Jan 2024 04:20
URI:	http://repository.ubaya.ac.id/id/eprint/45830

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