A Congenital Cytomegalovirus Infection : A Case Report

Retnaningtyas, Lucia Pudyastuti and Dinihari, Melati and Setyoboedi, Bagus (2024) A Congenital Cytomegalovirus Infection : A Case Report. In: 1st Pediatric Gastrohepatology Update Symposium, 31 May - 02 June 2024, Surabaya.

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Abstract

BACKGROUND Congenital Cytomegalovirus (CMV) infection is the most common congenital infection in worldwide cause of birth defect. It is a vertically transmitted infection that raises a heavy health burden for children and families. The infection is often unpredictable because most healthy adults including pregnant woman who acquire CMV infections have no or few symptoms and no long-term consequences. Our goal of reporting this case is to raise awareness of congenital CMV infection to ensure early detection and appropriate treatment of affected babies, with the goal of improving their prognosis and preventing the associated audiological and cognitive sequelae. CASE A female neonate, with a gestational age of 35 weeks and 1650 gram of birth weight was born by caesarean section for indications of severe pre-eclampsia in his mother. Soon after birth, the baby developed respiratory distress and had poor activity. The initial diagnosis was respiratory distress syndrome and was managed appropriately. Later, the baby developed conjugate neonatal hyperbilirubinemia and sepsis that was taken as a cause of it and obstructive causes were ruled out. The baby also had anemia, thrombocytopenia, prolonged jaundice, an intracranial calcification by ultrasound. The patient’s laboratory result revealed IgM anti CMV non reactive and IgG anti CMV reactive (234,9 ; non reactive < 6.0 AU/ml). The baby received methylprednisolone for about 6 weeks with initial dose 2 mg/kg/day then tappering off, iron supplementation 3 mg/kg/day and ursodecholic acid 10 mg/kg/dose. Out patient follow up for screening high risk baby was done, Oto Accoustic emission ( OAE ) has passed and examination and for eyes still on going. The body weight on 4 months old was 3948 kg, body lenght 52 cm and head circumference 37 cm. The last laboratory result on 3 months old showed the baby still has cholestasis , total bilirubin 3. 9 mg/dl , direct bilirubin 1.67 mg/dl. We still monitoring for the growth and development the patient. CONCLUSION: Congenital CMV infection must be considered as a cause of a small for gestational age neonate with poor feeding and conjugated hyperbilirubinemia. Appropriate therapy must be done soon to get a good outcome earlier.

Item Type:	Conference or Workshop Item (Poster)
Uncontrolled Keywords:	Congenital cytomegalovirus infection, neonatal hepatitis
Subjects:	R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions:	Faculty of Medical > Medical Study Program
Depositing User:	LUCIA PUDYASTUTI RETNANINGTYAS
Date Deposited:	03 Jun 2024 04:04
Last Modified:	03 Jun 2024 04:04
URI:	http://repository.ubaya.ac.id/id/eprint/46468

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