Cerebral Toxoplasmosis Therapy in a Patient with Human Immunodeficiency Virus: A Case Report

Aurellia, Livia and Badriyah, Rani Nur and Widya, Reta Anggraeni and Pratama, Jainuri Erik and Herawati, Fauna and Setiadi, Antonius Adji Prayitno and Gondokesumo, Marisca Evalina (2026) Cerebral Toxoplasmosis Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. Jurnal Teknologi Laboratorium, 15 (2). pp. 188-194. ISSN 2338-5634; E-ISSN 2580-0191

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Abstract

Toxoplasma infection or toxoplasmosis is an infectious disease caused by the parasite Toxoplasma gondii. Toxoplasma gondii infection of the central nervous system occurs in patients with immunodeficiency. The recommended first-line therapy is pyrimethamine + sulfadiazine + leucovorin, however, due to the unavailability of pyrimethamine, the alternative therapy that can be used is trimethoprim + sulfamethoxazole. We present a case of cerebral toxoplasmosis in a male patient, 31 years old, with HIV disease, admitted to the hospital with the main complaint, namely gradual disorder of consciousness (DOC) or decreased consciousness six days before entering the hospital. Initially, the patient looked confused. However, over time, the patient becomes increasingly challenging to communicate with. The patient is post-status general motor onset tonic seizure. The patient has had diarrhea for two months with black stools. The patient also had a fever. The patient received a combination therapy of Clindamycin 4x600mg and Cotrimoxazole 2x960mg. The combination of Clindamycin and Cotrimoxazole is recommended as an alternative therapy, but further research is needed regarding the outcome of therapy.

Item Type:	Article
Uncontrolled Keywords:	Cerebral Toxoplamosis; Human Immunodeficiency Virus (HIV); Clindamycin; Cotrimoxazole; Trimethoprim-sulfamethoxazole
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	19 Aug 2024 03:01
Last Modified:	22 Sep 2026 02:29
URI:	http://repository.ubaya.ac.id/id/eprint/46955

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