Effect of Giving Papaya Leaf Extract (Carica Papaya L.) on Changes in Fasting Blood Glucose in Male Wistar Rats (Rattus Norvegicus) Induced by Streptozotocin

Sudarisman, Gabriella Alisha and Sajuni, Sajuni and Hanum, Puri Safitri (2025) Effect of Giving Papaya Leaf Extract (Carica Papaya L.) on Changes in Fasting Blood Glucose in Male Wistar Rats (Rattus Norvegicus) Induced by Streptozotocin. International Journal of Medical Science and Clinical Research Studies, 5 (2). pp. 215-219. ISSN 767-8326, E-ISSN 2767-8342

PDF Effect of Giving Papaya Leaf Extract.pdf Download (230kB)

Abstract

Background: Diabetes mellitus is a disease characterized by an increase in blood glucose levels due to decreased insulin production or decreased insulin action. Diabetes cases are described as a serious problem globally in the 21st century and cases are increasing worldwide. One type of plant that can be used as a medicine is papaya leaf (Carica papaya L.) which is known to contain several active compounds such as flavonoids, saponins, tannins, and alkaloids. Objective: To determine the effect of papaya leaf extract (Carica papaya L.) on changes in fasting blood glucose levels of male Wistar rats with hyperglycemia conditions. Methodology: This research is an experimental research Randomized Controlled Trial (RCT) with Pretest-Postest Group Design study design. This study used 35 male white rats which were divided into 5 groups. Group I (without treatment), group II (STZ-NA), group III (STZ-NA and Glimepiride), group IV [papaya leaf extract at a dose of 150mg/Kg], group V (papaya leaf extract at a dose of 200mg/Kg). The data obtained after the study will be tested for normality which is then continued with non-parametric tests using the Kruskal-Wallis and Mann-Whitney U tests, and an effect size test is carried out to determine how much effect is produced from the papaya leaf extract given. Research Results: The administration of papaya leaf extract at a dose of 200mg/200grBody Weight in male Wistar rats in group 5 proved to reduce fasting blood glucose levels more significantly than the administration of glimepiride at a dose of 0.04 mg and papaya leaf extract at a dose of 150mg/Kg. Conclusion: Administration of papaya leaf extract (Carica papaya L.) can reduce fasting blood glucose levels in diabetic model rats effectively at a dose of 200mg/Kg.

Item Type:	Article
Uncontrolled Keywords:	Carica Papaya L, Diabetes, Blood Glucose
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	Ester Sri W. 196039
Date Deposited:	12 Feb 2025 06:54
Last Modified:	13 Feb 2025 04:20
URI:	http://repository.ubaya.ac.id/id/eprint/48006

Actions (login required)

View Item