Chemical and Physical Properties, Pharmacokinetics, and Pharmacodynamics of Curcumin Derivatives

Putra, Galih Satrio and Hasan, Muhammad Ainur and Sulistyowaty, Melanny Ika and Anwari, Farida and Kesuma, Dini (2025) Chemical and Physical Properties, Pharmacokinetics, and Pharmacodynamics of Curcumin Derivatives. In: Health Benefits of Curcumin. IntechOpen, pp. 1-22.

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Abstract

Curcumin derivatives (Curcuminoids) are a highly intriguing class of phytochemi- cal compounds, widely discussed due to their presence as active ingredients in various pharmaceutical formulations and food supplements. There are three main compounds in curcuminoids: curcumin, desmethoxycurcumin, and bisdemethoxycurcumin. These compounds exhibit distinct chemical structures, which significantly influence their chemical and physical properties, pharmacokinetic profiles, and pharmaco- dynamic characteristics. From a pharmacokinetic perspective, curcuminoid-based formulations present unique challenges due to their poor water solubility and low permeability in the gastrointestinal tract (GIT). In terms of pharmacodynamics, curcuminoids interact with multiple receptor targets and enzymes, contributing to a wide range of pharmacological effects, including anti-inflammatory, antioxidant, and anticancer activities, among others. Therefore, this book explores in depth the chemical and physical properties of curcumin derivatives and their impact on phar- macokinetic and pharmacodynamic profiles.

Item Type:	Book Section
Uncontrolled Keywords:	curcuminoid, curcumin, desmethoxycurcumin, bisdemethoxycurcumin, chemical–physical properties, pharmacokinetics, pharmacodynamics
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	14 Apr 2025 03:38
Last Modified:	14 Apr 2025 03:38
URI:	http://repository.ubaya.ac.id/id/eprint/48333

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