Wulansari, Devyani Diah and Khotib, Junaidi and Mustika, Arifa and Herawati, Fauna and Yulia, Rika and Yuniarta, Tegar Achsendo and Alkindi, Fawandi Fuad and Azminah, Azminah (2025) Chemical Profiling and In Silico Docking of Phytoconstituents as Prospective Immune Modulating Agents: Investigating The Therapeutic Potential of Fermented Garlic Honey. Egyptian Journal of Chemistry. ISSN 0449-2285; E-ISSN 2357-0245 (In Press)
Full text not available from this repository. (Request a copy)Abstract
Fermented Garlic Honey is a combination of honey and garlic (Allium sativum L.) that undergoes extraction and fermentation with varied soaking times. The combination of these two herbs will likely have a synergistic therapeutic effect that can be used as a functional food to promote a healthy lifestyle. This method evaluates chemicals in a sample based on the length of fermentation time, allowing it to predict the compounds that contribute to its biological activity. FTIR and LC-HRMS were used to identify secondary metabolites in Fermented Garlic Honey (FGH). Principal component analysis (PCA) may easily distinguish between samples based on the extraction solvent. LC-HRMS is an advanced analytical technique identifying 29 compounds in Raw Honey and 31, 34, and 34 compounds in the FGH at 2, 4, and 6 weeks samples, respectively. The bioactive substances meglutol, Gamma Glutamyl-S-Methylcysteine, Gamma Glutamyl-S-Allylcysteine, and S-Allylcysteine were found in the four samples and have been suggested to have therapeutic benefits as immunomodulating agents. Furthermore, Molegro Virtual Docker 7 has been utilized to predict the possible mode of action of the selected bioactive compounds. Among the compounds tested, Gamma-glutamyl-S-allylcysteine exhibited the most optimal interaction in three receptors (Caspase-1, INOS, and IL-1β). Our results imply that these bioactive chemicals found in FGH are predicted to have potential immunomodulatory capabilities, nevertheless still require verification through in vivo or in vitro studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Honey; Garlic; Obesity; Diabetes; Healthy lifestyle; S-Allylcysteine |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | DEVYANI DIAH WULANSARI |
| Date Deposited: | 08 Oct 2025 05:56 |
| Last Modified: | 08 Oct 2025 05:56 |
| URI: | http://repository.ubaya.ac.id/id/eprint/49699 |
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