Research overview on FOXO1 and its role in gestational diabetes mellitus through epigenetic lens: bibliometric analysis

Ikawaty, Risma and Sardiayanti, N.M.E.P and Baharuddin, Baharuddin and Putri, M.C. and Putra, M.D.A.R. and Angjaya, J.A. and Aji, R.A.R. Risang and Permana, S.V. and Putra, S.E.D. (2025) Research overview on FOXO1 and its role in gestational diabetes mellitus through epigenetic lens: bibliometric analysis. Diabetes Research and Clinical Practice, 230 (1). ISSN 1872-8227

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Abstract

Epigenetic studies showed various gene methylation in the placenta of women with gestational diabetes mellitus (GDM), which were connected to pathways for the metabolism of glucose and energy including FOXO1. Disruption of its expression has a profound effect on the pathogenesis of metabolic disorder. However, a global review of the development of FOXO1 methylation research in relation to GDM has not been conducted. Aim: To explore FOXO1 methylation research and the occurrence of GDM by using bibliometric analysis. Method: Bibliometric approach guided by PRISMA framework was applied to map the articles published in 2008-2023 from Scopus database using the keywords ‘‘methylation AND (”pregnant women‘‘ OR pregnancy) AND (diabetes OR ”gestational diabetes‘‘)” and ‘‘FOXO1 AND Diabetes” (accessed May 20, 2024). Results: A significant increase in the number of articles discussing DNA methylation and gestational diabetes (441 articles), FOXO1 and diabetes (887 articles) observed since 2008 to 2023. Network visualization of 441 articles revealed 4 clusters: epigenetic, pregnancy, gestational diabetes, and DNA methylation, while the 887 articles produced 4 clusters: type 2 diabetes, FOXO1, diabetes, and gluconeogenesis. DNA methylation closely tied to GDM, but no studies explored FOXO1 role in this process. FOXO1 strongly linked to diabetes but indirectly associated with GDM. Research on methylation has shifted toward cell-free DNA, neonatal outcomes, and macrosomia, while FOXO1 studies remain focused on cell signaling. These finding suggested further research potential. Conclusion: Increasing studies on the association of DNA methylation with GDM, but no research has specifically linked FOXO1 methylation with GDM. Current trends show growing interest examining the long-term impact of GDM on offspring.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	BAMBANG SEPTIAWAN
Date Deposited:	06 Jan 2026 04:09
Last Modified:	06 Jan 2026 04:09
URI:	http://repository.ubaya.ac.id/id/eprint/50015

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