Anti-inflammatory potential of Camellia sinensis L. extract in an LPS-induced ARDS lung cell model via modulation of CCL-2, CXCL-9 and IFN-γ expression

Azis, Rizal and Widowati, Wahyu and Priyandoko, Didik and Kusuma, Hanna Sari Widya and Triharsiwi, Dwi Nur and Nurjamil, Aris Muhamad and Ayuni, Vini and Hadiprasetyo, Dhanar Septyawan and Gondokesumo, Marisca Evalina and Quoc, Nguyen Bao (2025) Anti-inflammatory potential of Camellia sinensis L. extract in an LPS-induced ARDS lung cell model via modulation of CCL-2, CXCL-9 and IFN-γ expression. Medicinal Plants - International Journal of Phytomedicines and Related Industries, 17 (2). pp. 323-330. ISSN 0975-4261; E-ISSN 0975-6892

PDF Anti-inflammatory potential of Camellia sinensis L. extract.pdf Download (804kB)

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a severe and potentially life-threatening condition characterized by alveolar-capillary inflammation, leading to lung injury, pulmonary edema, and respiratory failure. Acute Respiratory Distress Syndrome (ARDS) poses a significant challenge in ICUs due to high incidence and high mortality rates, despite advances in medical care. Effective management and treatment strategies are crucial to improving outcomes for patients with ARDS. This study investigates the anti-inflammatory effects of Camellia sinensis L. extract (CSE), rich in epigallocatechin gallate (EGCG), on inflammation-related gene expression in ARDS lung cell model treated with lipopolysaccharide (LPS). Rat alveolar epithelial type II (L2) lung cells induced by LPS were used as the ARDS model and treated with various concentrations of CSE. The gene expressions of CCL-2, CXCL-9, and IFN-γ were analyzed by qRT-PCR. CSE treatment decreased expression of pro-inflammatory genes CCL-2, CXCL-9, and IFN-γ 1.56 μg/ml CSE concentration (p < 0.05). The results of the study revealed that CSE exhibited potential as an anti-inflammatory agent by inhibiting key inflammatory mediators, suggesting its therapeutic potential in managing ARDS.

Item Type:	Article
Uncontrolled Keywords:	Cytokines, Inflammation mediators, Phytotherapy, Plant extracts, Polymerase chain reaction
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	30 Jan 2026 08:42
Last Modified:	30 Jan 2026 08:42
URI:	http://repository.ubaya.ac.id/id/eprint/50222

Actions (login required)

View Item