Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys

Purnamayanti, Anita and Suharjono, Suharjono and Rahmadi, Mahardian (2025) Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 12 (3). pp. 372-381. ISSN 2580-8303

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Abstract

Background: Intravenous β-cyclodextrin administration poses an increased risk of toxicity. Objective: This study aimed to determine the nephrotoxicity of intravenous beta-cyclodextrin (BCD) and its underlying molecular mechanism. Methods: Sixteen Wistar rats were randomly assigned to the healthy or diabetic test groups, which received daily intravenous injection of water for injection or 6% beta-cyclodextrin solution, respectively, for 28 days. Histopathology was analyzed semi-quantitatively on a 0-5 score basis, and RT-PCR was used to quantify mRNA expression of HIF-1, HIF-2, IL-1, IL-6, IL-18, and eNOS. Results: There were no deaths in any group, and renal function declined in the test groups. Histopathological findings revealed abnormalities in vascular integrity, cellular infiltration/damage, and necrosis in the kidney, while the relative mRNA expression of hypoxia-inducible factors (HIFs), a marker of regional renal hypoxia, was upregulated. Conclusion: Intravenous administration of beta-cyclodextrin increases the risk of nephrotoxicity, and the molecular mechanisms underlying kidney injury are probably mediated by hypoxia-inducible factors-2α (HIF-2α). We strongly suggest that future research should be conducted with an adequate sample size.

Item Type:	Article
Uncontrolled Keywords:	beta-cyclodextrin, intravenous, toxicity, sub-chronic, death rate How
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Anita Purnamayanti Rahman 202021
Date Deposited:	18 Feb 2026 06:34
Last Modified:	18 Feb 2026 06:34
URI:	http://repository.ubaya.ac.id/id/eprint/50324

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