The Potential of Circulating Free DNA of Methylated Leptin Gene as aBiomarker for Type 2 Diabetes Mellitus

Anjelina, Novia and Humardani, Farizky Martriano and Putra, Sulistyo Emantoko Dwi (2025) The Potential of Circulating Free DNA of Methylated Leptin Gene as aBiomarker for Type 2 Diabetes Mellitus. Eduvest - Journal of Universal Studies, 5 (11). pp. 13745-13757. ISSN E-ISSN: 2775-3727 ; P-ISSN: 2775-3735

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Abstract

Eduvest –Journal of Universal StudiesVolume 5Number 11, November, 2025p-ISSN 2775-3735-e-ISSN 2775-3727The Potential of Circulating Free DNA of Methylated Leptin Gene as a Biomarker for Type 2 Diabetes Mellitus13745The Potential of Circulating Free DNA of Methylated Leptin Gene as aBiomarker for Type 2 Diabetes MellitusNovia Anjelina1, Farizky Martriano Humardani2, SulistyoEmantoko Dwi Putra3*1,3Universitas Surabaya, Indonesia, 2Universitas Brawijaya, Indonesia Email: emantoko@staff.ubaya.ac.id* ABSTRACTType 2 Diabetes Mellitus(T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, with a steadily increasing global prevalence. One of the risk factors for T2DM is Gestational Diabetes Mellitus(GDM), which refers to the body's inability to regulate glucose during pregnancy and significantly increases the risk of developing T2DM in both the mother and her offspring. Among the various metabolic changes observed in GDM, leptin has been widely studied for its role in energy metabolism and insulin resistance. Leptin levels generally increase in obesity and GDM conditions, and one influencing factor is epigenetic mechanisms, including DNA methylation. Increased methylation in the leptin gene promoter region has been associated with decreased leptin expression, indicating a potential pathway linking GDM to T2DM susceptibility in offspring. Given the importance of epigenetic regulation, analysis of leptin DNA methylation patterns—particularly through non-invasive detection of placental circulating free DNA (cfDNA)—has the potential to serve as a biomarker for detecting T2DM risk from prenatal stages. This approach not only offers early detection but also opens opportunities for more targeted preventive measures to reduce T2DM incidence in the future.

Item Type:	Article
Uncontrolled Keywords:	biomarkers; cfDNA; diabetes diagnosis; epigenetics; methylated leptin
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	BAMBANG SEPTIAWAN
Date Deposited:	20 Feb 2026 02:17
Last Modified:	20 Feb 2026 02:17
URI:	http://repository.ubaya.ac.id/id/eprint/50343

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