Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Paracetamol in a Patient with Diabetes Mellitus

Febriola, Nidya Tri Fitria and Muzayyanah, Binti and Lilasari, Sekar Puspita and Pratama, Jainuri Erik and Setiadi, Antonius Adji Prayitno and Herawati, Fauna and Gondokesumo, Marisca Evalina (2026) Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Paracetamol in a Patient with Diabetes Mellitus. Jurnal Teknologi Laboratorium, 15 (1). pp. 87-95. ISSN 2338-5634; E-ISSN 2580-0191

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Abstract

Paracetamol is an over-the-counter medication widely used for the management of fever and pain, resulting in a continuous increase in its consumption. Although generally considered safe and well tolerated, paracetamol may, in rare cases, cause severe and life-threatening adverse reactions, including Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). SJS/TEN is a severe drug reaction associated with high morbidity and mortality. We report a case of paracetamol-induced SJS/TEN in a patient with diabetes mellitus. The diagnosis was established based on clinical manifestations and a history of drug exposure. The patient was managed with supportive and pharmacological therapy under close monitoring, including careful glycemic control. This case report highlights the importance of vigilance for severe adverse drug reactions, even when commonly perceived safe medications are used.

Item Type:	Article
Uncontrolled Keywords:	Steven Johnson Syndrome; Toxic Epidermal Necrolysis; Diabetes Mellitus; Paracetamol
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	20 Apr 2026 03:28
Last Modified:	20 Apr 2026 03:28
URI:	http://repository.ubaya.ac.id/id/eprint/50649

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