Pharmacological Profiles and Recovery Predictors in Severe COVID-19

Wijono, Heru and Herawati, Fauna and Jaelani, Abdul Kadir and Octavia, Stefani Kartika and Ramdani, Dewi and Azminah, Azminah and Kantono, Kevin and Yulia, Rika (2026) Pharmacological Profiles and Recovery Predictors in Severe COVID-19. COVID, 6 (6). p. 103. ISSN 2673-8112

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Abstract

This study analyses the pharmacological profiles of medications administered to critically ill COVID-19 patients to evaluate their efficacy regarding recovery rates and duration of hospitalization. The results demonstrate a significant difference in clinical outcomes. While the administration of Ceftazidime, Ceftriaxone, and Oseltamivir was associated with negative survival trends, Dexamethasone and Favipiravir were associated with a fourfold higher probability of survival in severe cases. Notably, no pharmacological intervention significantly reduced the length of hospital stay; instead, recovery duration was primarily influenced by comorbidities such as obesity, cardiovascular disease, and diabetes. Furthermore, age and preexisting physiological conditions remained primary predictors of mortality. Observational analysis in our study for drug repurposing identified Amikacin, Remdesivir, and Rivaroxaban as potential therapeutic candidates. However, Dexamethasone was identified as the most effective treatment for recovery, likely due to a molecular structure with high potential binding affinity to the SARS-CoV-2 virus. These findings suggest that while specific repurposed drugs offer measurable benefits, patient history remains a critical determinant of outcomes, highlighting the necessity for further research to refine therapies against emerging viral pathogens.

Item Type:	Article
Uncontrolled Keywords:	COVID-19; antibiotics; antiviral; drug therapy
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	BAMBANG SEPTIAWAN
Date Deposited:	11 Jun 2026 05:42
Last Modified:	11 Jun 2026 05:42
URI:	http://repository.ubaya.ac.id/id/eprint/50822

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