Characterization of Hesperidin-PEG 1000 Solid Dispersion Prepared by Freeze Drying Method

Mikail, Aga and Pradana, Aditya Trias and Fitriani, Endang Wahyu and Winantari, Agnes Nuniek and Putranti, Astridani Rizky and Lee, Xandramela Limala Alicya Junaidi (2026) Characterization of Hesperidin-PEG 1000 Solid Dispersion Prepared by Freeze Drying Method. EKSAKTA : Berkala Ilmiah Bidang MIPA, 27 (04). pp. 536-548. ISSN Print 1411-3724 — Online 2549-7464

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Abstract

Hesperidin is a disaccharide-derivative bioflavonoid in BCS class II, insoluble in water but soluble in propylene glycol and polyethylene glycol, and its poor aqueous solubility may impair bioavailability, necessitating modification via solid dispersion. In this study, a hesperidin–PEG 1000 system was prepared at 1:1 and 1:6 hesperidin:PEG 1000 ratios using freeze‑drying. The systems were characterised for crystallinity, thermal behaviour, vibrational transitions, and particle morphology. PXRD patterns recorded over 2θ = 5–40° showed that both solid dispersions retained the main diffraction peaks of pure hesperidin with reduced intensities, indicating preservation of a predominantly crystalline structure. DSC thermograms revealed a hesperidin melting peak at 261.0 °C for the pure drug, which shifted to 248.6 °C and 241.0 °C for the 1:1 and 1:6 systems, respectively, without disappearance of the drug melting event. Data from FTIR and SEM further indicated only minor molecular interactions and limited morphological changes, and the characterisation results for both ratios were essentially identical. Taken together, these findings indicate that freeze‑drying hesperidin with PEG 1000 under the applied conditions did not convert hesperidin into an amorphous, molecularly dispersed solid dispersion, but yielded a predominantly crystalline, esperidin‑dominated system with minimal PEG 1000 incorporation.

Item Type:	Article
Uncontrolled Keywords:	Hesperidin, peg 1000, solubility, solid dispersion system,freeze drying
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	AGA MIKAIL
Date Deposited:	03 Aug 2026 06:57
Last Modified:	03 Aug 2026 06:57
URI:	http://repository.ubaya.ac.id/id/eprint/51091

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