Aryani, Ni Luh Dewi (2006) PENETAPAN NILAI PARAMETER LIPOFILISITAS (LOG P, JUMLAH TETAPAN π HANSCH DAN TETAPAN F REKKER) ASAM PIPEMIDAT. Jurnal Ilmiah Sains & Teknologi, 1 (2). pp. 93-100. ISSN 0216-1540
Preview |
PDF
penetapan nilai parameter_Abstract_2006.pdf Download (562kB) | Preview |
Preview |
PDF
penetapan nilai parameter_2006.pdf Download (807kB) | Preview |
Abstract
Lipophilicity is the most often used physicochemical property in quantitative structure- activity relationships (QSAR) studies because it is related to the absorption across biological membrane and the distribution between body fluid and lipid-rich phase of drugs. Its quantitative descriptor is the octanol-water partition coefficient (usually expressed as log P). The 1- octanol-water partition coefficient of pipemidic acid was determined by an experimental using the shake-flask method and by calculating from π Hansch and ƒ Rekker constant. The values of logarithmic intrinsic partition coefficient (IPC) and apparent partition coefficient (APC) of pipemidic acid were -2,03 ± 0,25 and -3,932 ± 0,25. The values of logarithmic partition coefficient, which were obtained by calculating of π Hansch and ƒ Rekker constant were -1,65 and -1,981, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Pipemidic acid, log P, π Hansch, ƒ Rekker |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Eko Setiawan 194014 |
| Date Deposited: | 03 Oct 2013 02:42 |
| Last Modified: | 23 Oct 2013 22:01 |
| URI: | http://repository.ubaya.ac.id/id/eprint/5204 |
Actions (login required)
 |
View Item |
