PENETAPAN NILAI PARAMETER LIPOFILISITAS (LOG P, JUMLAH TETAPAN π HANSCH DAN TETAPAN F REKKER) ASAM PIPEMIDAT

Aryani, Ni Luh Dewi (2006) PENETAPAN NILAI PARAMETER LIPOFILISITAS (LOG P, JUMLAH TETAPAN π HANSCH DAN TETAPAN F REKKER) ASAM PIPEMIDAT. Jurnal Ilmiah Sains & Teknologi, 1 (2). pp. 93-100. ISSN 0216-1540

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Abstract

Lipophilicity is the most often used physicochemical property in quantitative structure- activity relationships (QSAR) studies because it is related to the absorption across biological membrane and the distribution between body fluid and lipid-rich phase of drugs. Its quantitative descriptor is the octanol-water partition coefficient (usually expressed as log P). The 1- octanol-water partition coefficient of pipemidic acid was determined by an experimental using the shake-flask method and by calculating from π Hansch and ƒ Rekker constant. The values of logarithmic intrinsic partition coefficient (IPC) and apparent partition coefficient (APC) of pipemidic acid were -2,03 ± 0,25 and -3,932 ± 0,25. The values of logarithmic partition coefficient, which were obtained by calculating of π Hansch and ƒ Rekker constant were -1,65 and -1,981, respectively.

Item Type: Article
Uncontrolled Keywords: Pipemidic acid, log P, π Hansch, ƒ Rekker
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 03 Oct 2013 02:42
Last Modified: 23 Oct 2013 22:01
URI: http://repository.ubaya.ac.id/id/eprint/5204

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