FORMULATION AND PHYSICOCHEMICAL STABILITY OF 20% GLYCOLIC ACID CREAMS USING POLYACRYLAMIDE, C13-14 ISOPARAFFIN, LAURETH-7 AND COMBINATION OF POLYACRYLAMIDE, C13-14 ISOPARAFFIN, LAURETH 7 WITH A GLUKOLIPID OF VEGETABLE ORIGIN

Aryani, Ni Luh Dewi and Parfati, Nani and Swandayani,, Rica Marlia and Haliem, Angelina (2011) FORMULATION AND PHYSICOCHEMICAL STABILITY OF 20% GLYCOLIC ACID CREAMS USING POLYACRYLAMIDE, C13-14 ISOPARAFFIN, LAURETH-7 AND COMBINATION OF POLYACRYLAMIDE, C13-14 ISOPARAFFIN, LAURETH 7 WITH A GLUKOLIPID OF VEGETABLE ORIGIN. In: PROOCEEDINGS BALI INTERNATIONAL SEMINAR ON SCIENCE AND TECHNOLOGY 2011 : Strengthening Basic Sciences and Technology for Industrial Sustainability. Udayana University and UPN "Veteran" Jawa Timur, Bali, CI.7-1. ISBN 979-979-98623-1-0

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Abstract

Glycolic acid is a α-hydroxy acids (AHAs). It are used in skin lightening creams. It were developed formulation of 20% glycolic acid creams. The creams were made using 4% of polyacrylamide, C13-14 isoparaffin, laureth-7 as a thickening agent for cream gels and emulsions base and combination of 1.5% of polyacrylamide, C13-14 isoparaffin, laureth-7 and 5% of a glukolipid of vegetable origin as emulisufier agent. Then the physicochemical stabilities were tested using climatic chamber for 30 days at 40˚C with 75% Relative Humidity (RH). The parameters stability observed were organoleptic, droplet size, density, viscosity, emulsion type, phase separation, pH and concentration of acid glikolat.Organoleptis, droplet size, density, viscosity, type of emulsion and phase separation of all of creams were stable, but the pH decreased during the storage time. The time of the concentration of glycolic acid remaining to 90% in cream using using 4% of polyacrylamide, C13-14 isoparaffin, laureth-7 and using combination of using 4% of polyacrylamide, C13-14 isoparaffin, laureth-7 with 5% of a glukolipid of vegetable origin were 30 and 32 days respectively.

Item Type: Book Section
Uncontrolled Keywords: glycolic acid, cream, physicochemical stability
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 03 Oct 2013 07:06
Last Modified: 23 Oct 2013 22:04
URI: http://repository.ubaya.ac.id/id/eprint/5240

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