The Development of Transdermal Piroxicam Using HPMC Matrices With PVP K-30 as a Penetration Enhancer

Aryani, Ni Luh Dewi (2006) The Development of Transdermal Piroxicam Using HPMC Matrices With PVP K-30 as a Penetration Enhancer. In: Proceeding International Conference on New Techniques in Pharmaceutical, Biomedical & Analytical Research. Jember University Press, Jember, pp. 37-42. ISBN 979-8176-47-2

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Abstract

The physicochemical properties such as solubility, partition coefficient, and membrane permeability of a drug are required for formulating and estimating drugs absorption that pass through biological membranes. The research studied about solubility, partition coefficient in octanol-phosphate buffer, rabbit skin permeability and release from the transdermal delivery system of piroxicam with addition of 6% PVP K-30 in vitro into phosphate buffer solution pH 7.4 at temperature 320 ± 10C. The results showed that the solubility of piroxicam was 904.44 ± 20.92 μg/mL. The values of log IPC and APC were 1.99 ± 0.01 and 0.08 ± 0.01, respectively. The flux, permeability coefficient, and diffusion coefficient of the piroxicam permeation process were 2.07 x 10-4 μg/cm2/sec, 4.96 x 10-6 cm/minute, and 4.13 x 10-8 cm2/minute, respectively. The release mechanism of piroxicam from transdermal delivery system was more dominant by diffusion than erosion. The fluxes of piroxicam release were 0,169 and 0,107 mg/cm2/minute for formulation with 2% HPMC and 4% HPMC, respectively.

Item Type: Book Section
Uncontrolled Keywords: Piroxicam, HPMC, PVP K-30, Transdermal delivery
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Eko Setiawan 194014
Date Deposited: 23 Oct 2013 10:08
Last Modified: 24 Oct 2013 01:23
URI: http://repository.ubaya.ac.id/id/eprint/5796

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