ACUTE ORAL TOXICIY OF METHANOL SEED EXTRAC OF GLYCINE MAX (L.) MERR DETAM I AND II VARIETIES IN MICE

Islamie, Ridho and Septiana, Rizki and Astuti, Sofiyani and Yulia, Rika (2017) ACUTE ORAL TOXICIY OF METHANOL SEED EXTRAC OF GLYCINE MAX (L.) MERR DETAM I AND II VARIETIES IN MICE. In: 5th International postgraduate conference on pharmaceutical science, 17-18 May 2017, UiTM Selangor Malaysia.

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Abstract

The previous study has shown that soybean seeds (Glycine mas (L.) Merr) detam I and Detam II varieties have antioxidant activity. The purpose of this research was to evaluate the acute oral toxicity of the methanolic extract of Glycine mas (L.) Merr from both of these varieties. The test was conducted in Swiss Webster mice using the conventional method. Each extract was tested using twnty-five mice and divided into 5 groups, namely control group and four test groups, each given the extract at 78 mg ?kg body weight (b.w) 312,5 mg/kg b.w, 1250 mg.kg b.w and 5000 mg/kg b.w, respectively. The mice in all group were observed for behavioral pattern, physical conditions, body weight, organ to body weight ratio, organ histology and mortality. All of the parameter among experimental groups were comparable. The LD50 of each extract in mice were determined to be greater than 5000 mg/kg b.w and there were no signs of toxicity and mortality after the administration of each extract for 14 days. Result of the present study suggest that the methanolic extract of soybean seeds detam I and detam II varieties are safe after single adiministratio at high dose

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: glycine max, detam I, detam II, methanol extract, acute oral toxicity
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Rika Yulia
Date Deposited: 22 Mar 2018 10:44
Last Modified: 22 Mar 2018 10:44
URI: http://repository.ubaya.ac.id/id/eprint/31856

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