Formulation and physical stability test of oleanolic acid cream and gel

Kartini, Kartini and Fitriani, Endang Wahyu and Tansridjata, Laurances (2018) Formulation and physical stability test of oleanolic acid cream and gel. Pharmaciana, 8 (1). pp. 77-86. ISSN 2088 4559; e-ISSN: 2477 0256

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Abstract

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. This study aimed to (1) formulate oleanolic acid into topical dosage forms, i.e., cream and gel and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate, and cetyl alcohol as the cream base and carbomer as the gel base. The cream and gel were then evaluated with accelerated stability test (40±2°C/75±5% RH) and stability test at room temperature (27±2°C/73±5% RH) for six weeks. The physical stability was determined using the following parameters: the visual appearance, density, viscosity, and flow properties of cream and gel, as well as the emulsion type and particle size of the cream. Data analysis were performed using one sample t-test and paired t-test. The results showed that the oleanolic acid cream and gel were able to maintain their visual appearance, density, viscosity, and flow properties during the six-week storage. Also, the oleanolic acid cream was able to keep its particle size and emulsion type during the tests.

Item Type:	Article
Uncontrolled Keywords:	formulation, stability test, cream, gel, oleanolic acid
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Kartini
Date Deposited:	11 Jun 2018 02:38
Last Modified:	10 Sep 2021 02:49
URI:	http://repository.ubaya.ac.id/id/eprint/32538

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