Karina, Lidya (2018) MYOPATHY ADVERSE DRUG REACTION ASSOCIATED WITH LANSOPRAZOLE: A CASE REPORT. Media Pharmaceutica Indonesiana, 02 (01). pp. 35-40. ISSN 2527-9017
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Abstract
ABSTRACT Proton pump inhibitor has been reported to cause myopathic adverse drug reactions in several overseas countries. Unfortunately, this case has never been raised and has not received much attention in Indonesia. A case about myopathy associated with lansoprazole in 48-years old man has been recently reported in Indonesia. Assessment methods used were time series data collection followed by causality analysis using Naranjo Scale. The results of analysis revealed a Naranjo Scale of 9, which was interpreted as definite. This report concluded that lansoprazole could triggered myopathy adverse drug reaction in some sensitive patient. The mechanism presumably through inhibition of H+K+-ATPase in other tissue which can lead destruction of myofibril and leakage of calcium, pottasium, phosphate, myoglobin, creatine phosphokinase, lactate dehydrogenase, and aspartate transaminases from the muscle. This case report aims to remind health professionals to pay more attention at possible myopathy adverse drug reactions in the use of lansoprazole and other proton pump inhibitors, so that more serious adverse drug reactions could be prevented.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | LIDYA KARINA |
| Date Deposited: | 07 Feb 2019 03:41 |
| Last Modified: | 24 Mar 2021 16:00 |
| URI: | http://repository.ubaya.ac.id/id/eprint/34281 |
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