Development of New Monolithic Polysaccharide-Based Columns for HPLC Enantiomeric Separation

., Ratih and Asmari, Mufarreh and El Deeb, Sami (2018) Development of New Monolithic Polysaccharide-Based Columns for HPLC Enantiomeric Separation. In: Books of Abstracts 12th International Symposium on Pharmaceutical Sciences (ISOPS) June 26-29, 2018. Ankara University of Pharmacy Publication, Turkey, pp. 263-265. ISBN 978-975-136-378-3

[thumbnail of 12th International Syposiumon Pharmaceutical Sciences_Ratih.pdf]
12th International Syposiumon Pharmaceutical Sciences_Ratih.pdf

Download (10MB) | Preview


Chondroitin sulfate A and maltodextrin have been studied as potential chiral selectors to provide new polysaccharide-based chiral stationary phases. A capillary electrophoresis method has been involved to figure out the enantiomers recognition behaviour in the presence of chiral selector. Chondroitin sulfate A 0.3% w/v and maltodextrin 10% w/v which found to be the optimal values in CE were immobilized onto monolithic silica epoxy and monolithic silica amine columns by Schiff base reaction respectively. The immobilized chondroitin sulfate A-based and maltodextrin-based CSPs have shown intial enantiomeric separation of amlodipine and verapamil as model compound of by HPLC.

Item Type: Book Section
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy > Department of Pharmacy
Depositing User: Ester Sri W. 196039
Date Deposited: 13 Feb 2019 03:19
Last Modified: 13 Feb 2019 03:19

Actions (login required)

View Item View Item