The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review

Nathanael, Joshua and Suardana, Putu and Vianney, Yoanes Maria and Putra, Sulistyo Emantoko Dwi (2021) The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review. Chemical Biology & Drug Design, 39 (1). pp. 1-18. ISSN 1747-0285

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Abstract

Diabetes mellitus type 2 (T2D) is one of the metabolic disorders suffered by a global human being. Certain factors, such as lifestyle and heredity, can increase a person's tendency for T2D. Various genes and proteins play a role in the development of insulin resistance and ultimately diabetes in which one central protein that is discussed in this review is FoxO1. In this review, we regard FoxO1 activation as detrimental, promote high plasma glucose level, and induce insulin resistance. Indeed, many contrasting studies arise since FoxO1 is an important protein to alleviate oxidative stress and promote cell survival, for example, also by preventing hyperglycemic-induced cell death. Inter-relation to PPARG, another important protein in metabolism, is also discussed. Ultimately, we discussed contrasting approaches of targeting FoxO1 to combat diabetes mellitus by small molecules.

Item Type:	Article
Uncontrolled Keywords:	Akt pathway, diabetes, FoxO1, modulators, small molecules
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	Sulistyo Emantoko 61116
Date Deposited:	06 Jan 2022 04:59
Last Modified:	12 Apr 2022 06:29
URI:	http://repository.ubaya.ac.id/id/eprint/40914

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