Kesuma, Dini and Siswandono, Bambang Tri Purwanto and Rudyanto, Marcellino (2020) Synthesis and anticancer evaluation of N-benzoyl-N'-phenyltiourea derivatives against human breast cancer cells (T47D). Journal of Chinese Pharmaceutical Sciences, 29 (02). pp. 123-129. ISSN 1003-1057
Preview |
PDF
Synthesis_Dini Kesuma_1.pdf Download (1MB) | Preview |
Abstract
New anti-breast cancer compounds have been found and may prove to have stronger activity. To predict the activities of N-benzoyl-N'-phenylthiourea (BPTU) derivatives, namely N-(3-chloro)benzoyl-N'-phenylthiourea (3-Cl-BPTU) and N-(3,4-dichloro) benzoyl-N'-phenylthiourea (3,4-2Cl-BPTU) with Sirtuin-1 receptor (PDB code: 4I5I), molecular docking was conducted at the beginning of this study. The compounds were then synthesized from benzoyl chloride derivatives and N-phenylthiourea. Molecular structure was confirmed using FTIR, 1H NMR, 13C NMR and Mass Spectra, while the anticancer activity was tested in vitro against human breast cancer cells (T47D) using MTT assay. The results indicated that the anti-cancer activities of the test compounds were better than those of the hydroxyurea as the reference compound, evidenced by the Rerank Score (RS). Furthermore, cytotoxic effect of 3-Cl-BPTU (IC50: 0.43 mM) and 3,4-dichloro-BPTU (IC50: 0.85 mM) showed better result compared with hydroxyurea (IC50: 4.58 mM). Therefore, we concluded that these compounds could possess termendous potential as the candidate for a new anticancer drug.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | N-(3-chloro)benzoyl-N'-phenylthioureaN-; (3,4-dichloro)benzoyl-N'-phenylthiourea; Anticancer T47D cells SIRT1 |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | DONA PUSPITA BIANTARI |
| Date Deposited: | 02 Mar 2020 03:24 |
| Last Modified: | 12 Mar 2020 03:14 |
| URI: | http://repository.ubaya.ac.id/id/eprint/37508 |
Actions (login required)
 |
View Item |
