Formulation and characterization of the atenolol-β-cyclodextrin-poloxamer 188 ternary inclusion complex with solvent evaporation method

Rani, Karina Citra and Winantari, Agnes Nuniek and Rohman, Muhammad Habibur and Stephanie, Stephanie (2020) Formulation and characterization of the atenolol-β-cyclodextrin-poloxamer 188 ternary inclusion complex with solvent evaporation method. International Journal Of Pharmaceutical Research, 11 (Supp 1). pp. 513-522. ISSN 0975-2366

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Abstract

Purpose: The aim of this study was to develop a ternary inclusion complex of atenolol-ß-cyclodextrinpoloxamer 188 to enhance the dissolution of atenolol. Methodology:The ternary inclusion complex of atenolol-ß-cyclodextrin-poloxamer 188 in this study was developed into three different ratios (1:1:0.00075; 1:1:0.00015; 1:1:0.00225). The solvent evaporation method was employed to produce these inclusion complexes. The inclusion complexes were characterized using FT-IR, DSC, XRD and SEM. The obtained inclusion complexes were also evaluated to determine the drug content and dissolution parameters. Results: The results of FT-IR analysis exhibited interaction of atenolol, ß-cyclodextrin, and poloxamer 188 through hydrogen bonding in the inclusion complex. Results of DSC and XRD study suggested the conversion of atenolol from a crystalline form to amorphous form. SEM analysis of inclusion complexes revealed that atenolol was entrapped in the ß-cyclodextrin cavities and poloxamer 188 attached on the surface of ßcyclodextrin.The dissolution profile of these inclusion complexes showed enhancement of atenolol dissolution compare to pure atenolol. The inclusion complex using 1:1:0,00015 ratio performed the highest dissolution efficiency among three ratios. Therewere a 1.2 fold increases in dissolution efficiency of inclusion complexes compared to the pure drug. Applications/Originality/Value: In ternary inclusion complex, ß-cyclodextrin served as a versatile carrier to entrap the drug inside their cavity via hydrogen bound interaction. The addition of poloxamer 188 is also required to enhance aqueous solubility and fasten the rate of dissolution of atenolol. There was no study to develop a ternary inclusion complex of atenolol using ß-cyclodextrin and poloxamer 188.

Item Type:	Article
Uncontrolled Keywords:	atenolol; β-cyclodextrin; ternary inclusion complex; solvent evaporation
Subjects:	R Medicine > R Medicine (General) T Technology > TP Chemical technology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	KARINA CITRA RANI
Date Deposited:	24 Mar 2020 05:35
Last Modified:	20 Jan 2022 04:34
URI:	http://repository.ubaya.ac.id/id/eprint/37706

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