Kesuma, Dini and Nasyanka, A.L. and Rudyanto, M. and Siswandono, Siswandono and Purwanto, B.T. and Sumartha, I Gede Ari (2020) A Prospective Modification Structure: The Effect Of Lipophilic And Electronic Properties Of N-(Phenylcarbamothyoil)Benzamide Derivatives On Cytotoxic Activity By In Silico And In Vitro Assay With T47D Cells. Rasayan Journal of Chemistry, 13 (3). pp. 1914-1918. ISSN 0974-1496; e-ISSN: 0976-0083
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Abstract
Topliss aromatic modification structure considers two important properties, lipophilic and electronic. This study is to prove lipophilic and electronic properties effect of an anticancer lead compound N-(phenylcarbamothyoil) benzamide using in silico and in vitro method. We used in silico method that docked two derivatives (4-nitro and 4-methyl moieties) in the sirtuin-1 receptor (PDB ID: 4i5i) using autodock tools. They were screened for cytotoxic activity on T47D cells with MTT Method. The result showed that there were different activities in docking prediction and cytotoxic activity on T47D. 4-Nitro PCTB had more increased activity than 4-methyl.It was implied that electronic activity is more affecting cytotoxic activity than lipophilic properties.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Lipophilic Effect, Electronic Effect, N-(phenylcarbamothyoil)Benzamide, T47D Cell, In-silico |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Ester Sri W. 196039 |
| Date Deposited: | 01 Sep 2020 04:16 |
| Last Modified: | 01 Sep 2020 04:40 |
| URI: | http://repository.ubaya.ac.id/id/eprint/38050 |
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