ALOX5 Gene Polymorphism And Effects Of Omega-3 Fish Oil On Lung Function In Asthma

Lorensia, Amelia and Wahjudi, Mariana and Mayzika, Nadia Aisah (2020) ALOX5 Gene Polymorphism And Effects Of Omega-3 Fish Oil On Lung Function In Asthma. The Indonesian Journal Chest & Critical Emergency Medicine, 7 (2). pp. 23-31. ISSN 2614-2759; pISSN : 2355-4584

PDF Amelia Lorensia_ALOX5 GENE POLYMORPHISM AND EFFECTS OF OMEGA-3 FISH OIL_Rev.pdf Download (1MB)

Abstract

Background: Omega-3 as a local source plays a role in the arachidonic pathway in asthma therapy, related to an improvement of lung function. The anti-inflammatory effects of omega-3 are known to be related to genetic factors, one of which is on ALOX5 gene polymorphism Objective: This study aims to determine the profile of ALOX5 polymorphism and the effects of omega-3 fish oil on lung function in asthma in Surabaya Methods: The method was pre-experimental design, using a purposive sampling technique for data collection from June 2017 to January 2018 in Surabaya. The intervention provided was fish oil which contains 1000 mg of omega-3 for 1 month. The different test using paired t-test to compare before and after getting the intervention. The research subjects were 27 adult outpatient asthmatics and 23 non-asthma patients (as the comparison on genetic testing. Results: The results of improvement in lung function showed a significant difference (p=0.00) in PEF0 values (average: 217,96L/sec) and PEF4 (average: 325,00L/sec). Of the 27 study subjects, only 23 people could have genetic testing by a buccal swab. Asthma patients had more mutant II genotypes (39,13%) than wild types (30,43%). In this study, the relationship between ALOX5 gene polymorphism and lung function improvement cannot be tested because the number of samples is relatively limited. There was one subject who had constant PEF value (mutant II) and decreased PEF value (mutant III) Conclusion: Fish oil is effective in improving lung function, especially in asthma patients with wild genotype type.

Item Type:	Article
Uncontrolled Keywords:	ALOX5, asthma, PEF, fish oil, omega-3
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	29 Oct 2021 05:59
Last Modified:	29 Oct 2021 07:13
URI:	http://repository.ubaya.ac.id/id/eprint/40660

Actions (login required)

View Item