Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product

Furwanti, Cece and Hendrajaya, Kusuma and indrayanto, Gunawan (2020) Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product. Media Pharmaceutica Indonesiana, 3 (1). pp. 27-36. ISSN 1411-8734

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Abstract

Antihemoroid® suppository has been produced commercially by PT. Kimia Farma, Indonesia. For QC purposes, a separated densitometric method for analysis of its active ingredients, lidocaine hydrochloride and hexachlorophene, was applied. The objective of this study was obtaining more efficient analysis method of LH and HC, therefore an HPLC procedure has been developed for the determination of both compounds simultaneously. AYMC-Triart C18 column was used with a gradient mobile phase consisting of acetonitrile and phosphate buffer 0.05 M (pH 6.0). Quantitative evaluation was performed at 220 nm. Method validation was performed according to the new methods of USP 41. Result showed that the HPLC method was simple, accurate, precise, and robust. The HPLC method can be applied in simultaneous determination of LH and HC in suppositories as a QC tool in the pharmaceutical industries.

Item Type:	Article
Uncontrolled Keywords:	hexachlorophene; HPLC; lidocaine HCl; method validation; suppository
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	KUSUMA HENDRAJAYA - 203006
Date Deposited:	11 Nov 2021 06:38
Last Modified:	11 Nov 2021 06:38
URI:	http://repository.ubaya.ac.id/id/eprint/40711

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