Synthesis and cytotoxic activity of N-(2,4-dichloro)benzoyl-N’- phenylthiourea against human breast cancer cell line

Kesuma, Dini and Putra, Galih Satrio and Yuniarta, Tegar Achsendo (2022) Synthesis and cytotoxic activity of N-(2,4-dichloro)benzoyl-N’- phenylthiourea against human breast cancer cell line. Thai Journal of Pharmaceutical Sciences (TJPS), 46 (2). pp. 173-176. ISSN 1905-4637 P-ISSN(s): 0125-4685

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Abstract

Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D NMR, and mass spectra. Furthermore, it is shown that the synthesized compound possesses better cytotoxicity profile than hydroxyurea. Conclusion: N-(2,4-dichloro)benzoyl-N’-phenylthiourea is a potential thiourea analog as anticancer agent, albeit further research is needed.

Item Type:	Article
Uncontrolled Keywords:	Schotten-Baumann, phenylthiourea, anticancer activity
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	10 Jun 2022 05:30
Last Modified:	10 Jun 2022 05:30
URI:	http://repository.ubaya.ac.id/id/eprint/41960

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