Potential Application Of Clitoria ternatea In Cancer Treatment

Purnamayanti, Anita and Gondokesumo, Marisca Evalina and Budipramana, Krisyanti (2022) Potential Application Of Clitoria ternatea In Cancer Treatment. Pharmaceutical Sciences and Research (PSR), 9 (3). pp. 109-124. ISSN 2407-2354; E-ISSN: 2477-0612

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Abstract

Clitoria ternatea flowers, commonly known in Indonesia as bunga telang, are a natural colored blue mixture in food and beverages. Many Indonesians used bunga telang as traditional medicine for eyes, urinary disease, skin disease, and anti-toxin. Along with the development of science and technology, C. ternatea flower has been found to have high polyphenol content, several types, including saponins, tannins, steroids, triterpenoids, kaempferol, and quercetin which proved to have anticancer activity. This review article aims to identify and analyze recent studies related to the phytochemical activities of C. ternatea flower extract against cancer cells. In addition, the report about the toxicity study C. ternatea flower extract was reviewed to find out the safety for human consumption and application. The current research on C. ternatea related to the study objective published from 2011 to 2021 will be selected and reviewed. Research on various extracts of C. ternatea flower showed the moderate cytotoxic (IC50 = 21 μg/mL — 200 μg/mL) for several types of cancer cell lines such as MCF-7, MDA-MB-231, CaoV-3, HEp-G2 trough aquadest extraction as well as for cell line DLA in petroleum ether extract. The anticancer activity of C. ternatea flower extract has played roles by ternatins, delphinidin, kaempferol, quercetin, sitosterol, and tocopherols. Meanwhile, the extraction flower of C. ternatea has not any reported any toxic activity in normal cells (Hs27) and oral consumption in mice. Based on numerous studies, C. ternetea flower extract has been shown to have activities on multi-molecular targets with the most conclusive effect on polyperase enzyme. These findings suggest a potential application of C. terneta in cancer treatment.

Item Type:	Article
Uncontrolled Keywords:	Clitoria ternatea flower, phytochemical activity, anticancer activity, multi molecular targets
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	28 Jun 2022 09:11
Last Modified:	17 Feb 2023 04:02
URI:	http://repository.ubaya.ac.id/id/eprint/42015

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