Effect of Asiatic Acid Intranasal Administration on Brain-Derived Neurotrophic Factor (BDNF) Expression in the Scopolamine-Treated Mice

Myint, Su Lwin Lwin and Islamie, Ridho and Benya-aphikul, Hattaya and Rojanaratha, Tissana and Ritthidej, Garnpimol and Rodsiri, Ratchanee (2022) Effect of Asiatic Acid Intranasal Administration on Brain-Derived Neurotrophic Factor (BDNF) Expression in the Scopolamine-Treated Mice. In: The Proceedings of The Joint Physiological Pharmacological Society Conference JPPSC-2022, 8-10 Juni 2022, Thailand.

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Abstract

Brain-derived neurotrophic factor (BDNF) plays a key role in pathogenesis of learning and memory impairment. Alteration of BDNF levels is one of the neuroprotective strategies. Asiatic acid (AA) possessed antioxidant, anti-inflammatory, and acetylcholinesterase inhibition activities. However, an intensive metabolize by CYP450 in the gastrointestinal tract has limited AA availability in the brain. This study aimed to investigate the effect of intranasal administration of AA on the level of BDNF in scopolamine-treated mice. For 10 days, AA was administered intranasally (2.3 mg/kg) or orally (3, 30, or 100 mg/kg) to ICR mice and then scopolamine (3 mg/kg) was administered intraperitoneally. BDNF levels in the hippocampus and prefrontal cortex were measured by western blot analysis. Mice received scopolamine alone and oral AA with scopolamine had the significant decreased BDNF levels in the hippocampus. Intranasal AA administration significantly increased BDNF levels in the hippocampus compared to oral AA administration groups. BDNF levels in the prefrontal cortex was no significant difference among groups. The protective effect of intranasal AA was superior to oral administration of AA. Intranasal administration of AA can protect the reduction of BDNF levels in the hippocampus which is the brain region involved in the learning and memory process.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	Brain-derived neurotrophic factor (BDNF), asiatic acid, intranasal, scopolamine
Subjects:	Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	28 Jul 2022 02:42
Last Modified:	30 Mar 2023 06:13
URI:	http://repository.ubaya.ac.id/id/eprint/42232

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