The Role of Immune Checkpoints in Cancer Progression

Prasetya, Rahmad Aji and Wulansari, Devyani Diah (2022) The Role of Immune Checkpoints in Cancer Progression. In: Regulatory T Cells. InTech, London, pp. 1-18. ISBN 978-1-80356-057-1; Print ISBN 978-1-80356-056-4; eBook (PDF) ISBN 978-1-80356-058-8

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Abstract

Immune checkpoint proteins are like two-faced swords that first act as gatekeepers of the immune system to protect the host from tissue damage. In contrast, these proteins can corroborate cancer progression by inhibiting tumor-specific immune responses. Here, we summarized the regulation and signaling cascade of immune checkpoints molecules (PD-1/PD-L1, CTLA-4, TIM3, TIGIT, LAG3, and BTLA), including their role in providing co-inhibitory signals for regulating T-cell response. The involvement of immune checkpoint molecules to drive cancer growth is elaborated with explanations about various anticancer strategies, such as (1) the overexpression of immune checkpoints in cancer cells, immune cells, or the surrounding environment leading to incapabilities of the tumor-specific immune response, (2) immune checkpoints interference to metabolic pathways then deplete nutrients needed by immune cells, (3) the interaction between immune checkpoints and regulatory T cells. Lastly, future challenges of immune checkpoint inhibitors are discussed briefly to get insight into their applicability in the clinical setting.

Item Type:	Book Section
Uncontrolled Keywords:	immune checkpoint proteins, cancer development, anti-tumor, metabolic reprogramming, regulatory T cells
Subjects:	Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	DEVYANI DIAH WULANSARI
Date Deposited:	31 Mar 2023 04:47
Last Modified:	02 Nov 2023 07:29
URI:	http://repository.ubaya.ac.id/id/eprint/43703

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