Neurogenomics of Alzheimer’s disease (AD): An Asian population review

Besin, Valentinus and Humardani, Farizky Martriano and Mulyanata, Lisa Thalia (2023) Neurogenomics of Alzheimer’s disease (AD): An Asian population review. Clinica Chimica Acta, 546 (117389). pp. 1-9. ISSN 1873-3492(Online); 0009-8981(Print)

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Abstract

Alzheimer’s disease (AD) is on the rise worldwide. Generally, AD is considered neurodegenerative when the production and clearance of amyloid-β (Aβ) are imbalanced. Recent research on genome-wide association studies (GWAS) has been explosive; GWAS indicates a relationship between single nucleotide polymorphism (SNP) and AD. GWAS also reveals ethnic differences between Caucasians and Asians. This indicates that pathogenesis be- tween ethnic groups is distinct. According to current scientific knowledge, AD is a disease with a complex pathogenesis that includes impaired neuronal cholesterol regulation, immunity regulation, neurotransmitters regulation, Aβ clearance, Aβ production, and vascular regulation. Here, we demonstrate the pathogenesis of AD in an Asian population and the SNP risk of AD for future AD screening before onset. According to our knowledge, this is the first review of Alzheimer’s disease to demonstrate the pathogenesis of AD based on SNP in an Asian population.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer’s Disease; Amyloid-β; Asian; Single nucleotide polymorphism; Genomics
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	Ester Sri W. 196039
Date Deposited:	24 May 2023 08:59
Last Modified:	24 May 2023 08:59
URI:	http://repository.ubaya.ac.id/id/eprint/44201

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