The effect of oral anticoagulant use before visit for patients with COVID-19 on mortality: A meta-analysis

Ghea, Cornelia and Wardhana, Ardyan Prima and Nugroho, Alfredo and Assilmi, Fika Humaeda (2023) The effect of oral anticoagulant use before visit for patients with COVID-19 on mortality: A meta-analysis. Tzu Chi Medical Journal, 35 (3). pp. 226-230. ISSN 1016-3190

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Abstract

Objectives: Anticoagulants have been used as therapeutic or prophylactic agents in COVID-19 and seem to be more beneficial. However, the advantage of oral anticoagulant (OAC) consumption before visit in lowering mortality in COVID-19 patients remains debatable. This meta-analysis aimed to evaluate the effect of OAC use before visit on mortality using the hazard ratio (HR) to estimate the effect of time-to-event endpoints. Materials and Methods: We conducted a literature search in the PubMed and ProQuest databases for any studies comparing groups consuming OAC to no-OAC before visit for mortality in patients with COVID-19. We calculated the overall HRs and their variances across the studies using the random-effects model to obtain pooled estimates. Results: We included 12 studies which had sample sizes ranging from 70 to 459,402 patients. A meta-analysis comparing OAC therapy and non-OAC consumption in COVID-19 patients before visit revealed no decrease in all-cause mortality (HR = 0.92, 95% confidence interval [CI]: 0.83–1.02, P = 0.12; I2 = 68%). However, subgroup analysis of laboratory-confirmed populations revealed that OAC use before visit had a beneficial effect on mortality (HR = 0.84, 95% CI: 0.73–0.98, P = 0.02; I2 = 56%). Conclusion: The use of OAC before visit had no beneficial effect on all-cause mortality in COVID-19 patients.

Item Type:	Article
Uncontrolled Keywords:	Anticoagulation, COVID‑19, Direct oral anticoagulant, Mortality, Oral anticoagulant
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	ARDYAN PRIMA WARDHANA
Date Deposited:	21 Jul 2023 07:04
Last Modified:	06 Feb 2024 05:59
URI:	http://repository.ubaya.ac.id/id/eprint/44533

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