Avanti, Christina and Sumiyani, Ririn and Aprilia, Dini (2023) Hydrogen Peroxide Plasma Sterilization Sabotage the Efficacy of Lidocaine HCl Injection. The Open Anesthesia Journal, 17. (In Press)
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Abstract
Background: Lidocaine HCl 2% as an anesthetic drug must guarantee its sterility to avoid microbial contamination. In efforts to maintain the sterile preparation of Lidocaine HCl 2% before use in hospitals, some anesthesiologists opt for re-sterilization. Objective: To evaluate the impact of plasma sterilization using hydrogen peroxide on Lidocaine HCl levels employing validated Ultra Performance Liquid Chromatography (UPLC) assay. Methods: The 2% Lidocaine HCl samples were separated into two groups, one undergoing re-sterilization with hydrogen peroxide and the other handled only with aseptic techniques. The chromatographic assay was performed using a Waters Corp Acquity UPLC® H-Class system and a Waters Corp Acquity UPLC® BEH C18 column, with a mobile phase of 20% Acetonitrile and 80% Acetate Buffer pH 3.4, flow rate of 0.3 mL/min and total duration of 4.5 minutes. Results: The results showed a decrease in Lidocaine HCl levels to 1.88% after re-sterilization and 2.01% without re-sterilization. Conclusion: These findings suggest that re-sterilization with hydrogen peroxide plasma sterilization leads to a significant decrease in Lidocaine HCl levels, causing non-compliance with pharmacopeia standards.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hydrogen Peroxide, Plasma Sterilization, Lidocaine HCl, Anesthetic Drugs, Sterility, UPLC |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | Christina Avanti 1135 |
| Date Deposited: | 22 Sep 2023 08:49 |
| Last Modified: | 25 Oct 2023 04:10 |
| URI: | http://repository.ubaya.ac.id/id/eprint/44984 |
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