Hyperuricemia, use of antituberculosis drugs, and liver injury: Case Report

Yuwantari, Vina and Oktafiyani, Nur and Ningrum, Nurmelinda Hadi and Pristantiningtyas, M. Hari and Dharma, Herya Putra and Muchlis, Muhammad and Pratama, Jainuri Erik and Herawati, Fauna and Setiadi, Antonius Adji Prayitno and Gondokesumo, Marisca Evalina (2023) Hyperuricemia, use of antituberculosis drugs, and liver injury: Case Report. Jurnal Teknologi Laboratorium, 12 (1). pp. 40-45. ISSN 2338-5634; E-ISSN 2580-0191

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Abstract

Anti-tuberculous drug can cause idiosyncratic drug-induced liver injury (DILI). Considering the benefit risk, there will discontinuation therapy and rechallenge after symptom resolve. In addition to anti-tuberculosis drugs, liver injury can occur in patients with hyperuricemia. We report a 60-year-old male patient who had just used the initiation phase of OAT for 20 days experiencing hepatotoxic side effects characterized by complaints of nausea and vomiting for one week. Liver function examination results were normal with AST 23 u/L and ALT 9 u/L. OAT administration was temporarily stopped and started gradually with 150 mg rifampicin, 150 mg isoniazid and 500 mg ethambutol. The second day after using OAT again, given the full dose of 300 mg rifampicin, 300 mg isoniazid and 1000 mg ethambutol. The patient's condition improved after thismodification of therapy so that therapy with three anti-TB drugs was continued until he was discharged from the hospital.

Item Type:	Article
Uncontrolled Keywords:	Adverse effect, Antituberculosis, Drug induced liver injury
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	02 Jan 2024 06:16
Last Modified:	29 Jan 2024 03:55
URI:	http://repository.ubaya.ac.id/id/eprint/45565

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