Modulation of Immune Response from FiberCreme-VCO Based Supplementation in Immunosuppressed Rats

Wulansari, Devyani Diah and Winarni, Dwi and Sapei, Lanny and Gondokesumo, Marisca Evalina (2024) Modulation of Immune Response from FiberCreme-VCO Based Supplementation in Immunosuppressed Rats. Biomedical and Pharmacology Journal (BPJ), 17 (1). pp. 271-279. ISSN 0974-6242; e- ISSN: 2456–2610

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Abstract

Immunomodulators are substances that have the ability to influence the human immune system. FiberCreme is a commercial non-dairy food high in oligosaccharides, which are difficult to digest. Combination of FiberCreme and VCO (FC-VCO) considered to possess high value of bioavailability in body. This study was aimed to determine immunomodulation effect of FiberCreme-VCO against immunosuppressed rats. This study used male rat (Rattus novergicus) which was induced by doxorubicin twice a week for seven days. Treatment by FC-VCO was then administered orally for 14 days. Whole blood and spleen were collected and analyzed based on immunomodulator parameters such as spleen weight, body weight, IL-6, TNF-a, and INF-? levels, the CD4+/CD8+ ratio and the percentage of FOXP3. Statistical analysis was determined by GraphPad Prism software (version 9: San Diego, CA, USA). Regardless of dosage, FC-VCO did not improve body weight or lymphatic weight appreciably. In contrast to the negative group, FC-VCO supplementation at a dose of 6 mg/kgBW was able to raise CD4+ levels, and this difference was statistically significant (p<0.05). IFN-? levels were also increased by FC-VCO at a dose of 9 mg/kgBW, and these differences were statistically significant (p <0.05) when compared to the negative group. Since FC-VCO affects the roles and responsibilities of CD4+ and IFN-? in immunosuppressive situations, it can strengthen the immune system.

Item Type:	Article
Uncontrolled Keywords:	Doxorubicin; FiberCreme; Healthy Life; Immunomodulator; Virgin Coconut Oil
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology T Technology > TP Chemical technology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	DEVYANI DIAH WULANSARI
Date Deposited:	06 Jun 2024 07:10
Last Modified:	06 Jun 2024 07:12
URI:	http://repository.ubaya.ac.id/id/eprint/46502

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