Nawatila, Roisah and Azminah, Azminah (2023) Drug-Likeness Prediction And Anti-Anxiety Activity Test (In Silico) Of Lavandula angustifolia Essential Oil And Its Formulation Into Aromatherapy Roll On. In: The International Conference Scientific Meeting in Current Health Sciences and Drug Development, November 4th, 2023, Malang.
![[thumbnail of Abstract]](/style/images/fileicons/application_pdf.png) |
PDF (Abstract)
(EDIT) ABSTRAK FERRY.pdf - Other Restricted to Registered users only Download (156kB) | Request a copy |
Abstract
Background: Anxiety is one of the most common psychological disorders in the world. Anxiety can be overcome with pharmacological treatment such as benzodiazepines by binding to GABAA receptors. The use of drug therapy for anxiety can be complemented by aromatherapy to support the healing process. Aromatherapy uses essential oils as the main ingredient extracted from plant compounds. The essential oil of Lavandula angustifolia has benefits as an anti-anxiety therapy. This aromatherapy needed to be developed into a roll-on that is more stable and more effective to use. Methods: This study aims to determine the prediction of drug-likeness and anti-anxiety activity of essential oil compounds of Lavandula angustifolia by molecular docking method in silico against GABA PDB receptors code 6X3X using the Autodock Vina program. After that, the research will continue to develop the essential oil into aromatherapy roll on by determining the effect of different types of carrier oil in F1, F2, F3 (olive oil, caprylic triglyceride, virgin coconut oil, respectively) on the physical characteristics (organoleptic, homogeneity, pH, viscosity, acceptability test) and roll on stability (days 0, 7, 14, and 28). Results: The results of molecular docking showed that the essential oil of Lavandula angustifolia were 28 compounds that met drug-likeness and there were 4 compounds with a bond interaction suitability of 57%. The results showed that all formulas have good physical characteristics (homogeneity, pH, viscosity, and acceptability). However, F2 and F3 showed more attractive organoleptic results than F1. All formulas showed good physical stability results on days 0, 7, 14, and 28. Conclusions: From this study, the essential oil compound of Lavandula angustifolia has activity against GABAA receptors, so that it can be used as a complementary therapy in anti-anxiety. Additionally, variation types of carrier oil can affect the physical characteristics of aromatherapy roll on preparations.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | Anxiety, Aromatherapy, Lavandula angustifolia, In Silico, Roll On |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Pharmacy > Department of Pharmacy |
| Depositing User: | ROISAH NAWATILA |
| Date Deposited: | 17 Mar 2025 08:30 |
| Last Modified: | 17 Mar 2025 08:30 |
| URI: | http://repository.ubaya.ac.id/id/eprint/48227 |
Actions (login required)
 |
View Item |
