Kajian Pembentukan Dispersi Padat Atenolol Menggunakan Metode Freeze Drying

Maulita, Arina Swastika and Winantari, Agnes Nuniek and Rani, Karina Citra and Pradana, Aditya Trias and Kesuma, Dini (2025) Kajian Pembentukan Dispersi Padat Atenolol Menggunakan Metode Freeze Drying. MPI (Media Pharmaceutica Indonesiana), 7 (1). pp. 112-123. ISSN 2527-6298; e-ISSN 2527-9017

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Abstract

Atenolol is a selective β1-adrenoblocker drug used to treat cardiovascular conditions such as hypertension and angina pectoris. However, atenolol has low solubility and permeability, which can limit its oral bioavailability. One effective method to increase the solubility and dissolution rate of drugs with low solubility is through the formation of solid dispersions. Solid dispersions involve drug carriers in an inert matrix in the solid state, which can increase the solubility and stability of the drug. The freeze drying (lyophilization) method is used in the preparation of atenolol solid dispersions to avoid thermal decomposition and produce homogeneous molecular dispersions. Characterization of the resulting solid dispersions includes morphological analysis, identification of functional groups, crystallinity properties, thermal analysis, particle size, particle size distribution, and zeta potential. Various previous studies have shown that solid dispersions can significantly increase the solubility and dissolution rate of atenolol.

Item Type:	Article
Uncontrolled Keywords:	atenolol; bioavailabilitas; dispersi padat; freeze drying; kelarutan; laju disolusi
Subjects:	T Technology > TP Chemical technology
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	AGNES NUNIEK WINANTARI 202027
Date Deposited:	13 Aug 2025 02:44
Last Modified:	13 Aug 2025 02:44
URI:	http://repository.ubaya.ac.id/id/eprint/49403

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