Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis

Priambodo, Kristiadi and HY, Jefman Efendi Marzuki and Ikawaty, Risma and Baharuddin, Baharuddin and Syafika, Salsa Bella Destri (2025) Navigating the Cyp2 Gene Family Research Landscape: A Comprehensive Bibliometric Analysis. In: Proceedings of the 1st International Conference on Medical Science and Health ICOMESH, November 28-29, 2023, Bandar Lampung.

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Abstract

This study elucidates the role of the CYP2 gene family in the pharmacokinetics and pharmacodynamics of drugs. The variability in these genes significantly influences drug efficacy and individual response. With the increasing volume of scientific publications, a comprehensive understanding of the current research on the CYP2 gene family is crucial. Numerous studies have examined these genetic variations, yet a thorough assessment of this research landscape and the identification of unexplored areas are still needed. Through bibliometric analysis and global mapping, this study enables a more systematic interpretation of publication data, offering new insights. The aim is to perform scientific mapping and interpretation of the CYP2 gene family research corpus. Utilizing literature review methods and bibliometric analysis based on PRISMA guidelines, a search in the Scopus database with the keyword cyp2* yielded 11,867 articles. After cleaning and preparation, 9,439 articles remained for analysis. The results indicate a significant increase in CYP2 gene research, particularly between 2012-2023. Mapping reveals five main clusters, with CYP2E1 and CYP2D6 as the largest. CYP2C9 stands out for its polarization with three other clusters, indicating strong research collaboration. Identified strategic areas include opioids, atrial fibrillation, PCI, DNA methylation, hepatocellular carcinoma, and bile acid. Key genes in polymorphism studies include CYP2C19 and CYP2C8, while CYP2D6 is crucial in drug monitoring. This science mapping provides essential insights for research development in precision medicine.

Item Type:	Conference or Workshop Item (Paper)
Additional Information:	ISBN: 978-989-758-740-5
Uncontrolled Keywords:	Mapping of science, CYP2 gene, precision medicine, bibliometrik.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Medical
Depositing User:	BAMBANG SEPTIAWAN
Date Deposited:	23 Oct 2025 08:56
Last Modified:	24 Oct 2025 01:54
URI:	http://repository.ubaya.ac.id/id/eprint/49740

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