A 4-year cross-sectional study on the basic demography and Clopidogrel resistance profile

Besin, Valentinus and Humardani, Farizky Martriano and Notopuro, Paulus Budiono (2025) A 4-year cross-sectional study on the basic demography and Clopidogrel resistance profile. Acta Biomedica (ActaBiomed), 96 (6). 17337/1-6. ISSN 0392-4203; E-ISSN 2531-6745

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Abstract

Background and aim: Stroke is a leading cause of death and disability worldwide. Clopidogrel is widely used to prevent recurrent strokes in acute ischemic stroke patients, but clopidogrel resistance remains a significant concern due to various factors. While extensive research has been conducted on this issue, data from East Java are limited, and many cases are overlooked by clinicians. This study aimed to address this gap. Methods: We conducted a cross-sectional study involving 108 stroke patients aged 30–80 years who were not using proton pump inhibitors (e.g., omeprazole, esomeprazole) and had been on clopidogrel therapy for at least seven days. Clopidogrel resistance was evaluated using the VerifyNow assay. Results: Out of 108 patients, 27 (25%) were classified as having a bleeding risk. In terms of clopidogrel sensitivity, 79 patients (73%) were sensitive, while 29 (27%) were resistant. Among resistant cases, 17 were male and 12 were female. Age signifi- cantly influenced bleeding risk (p = 0.006), but not clopidogrel sensitivity (p = 0.135). Gender had a signifi- cant impact on inhibition levels (p = 0.009), as well as on base score (p = 0.009) and PRU score (p = 0.035). Conclusions: A notable proportion of stroke patients in East Java exhibited clopidogrel resistance, with males showing higher resistance rates. Age was a significant factor for bleeding risk, while gender influenced inhi- bition levels and PRU scores. Further research is needed to explore the underlying reasons for the observed gender differences in clopidogrel resistance. (www.actabiomedica.it)

Item Type:	Article
Uncontrolled Keywords:	age, clopidogrel, gender, resistance, sensitivity
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medical
Depositing User:	Ester Sri W. 196039
Date Deposited:	19 Dec 2025 05:34
Last Modified:	19 Dec 2025 05:34
URI:	http://repository.ubaya.ac.id/id/eprint/49986

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