The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells

Girsang, Ermi and Wargasetia, Teresa Liliana and Rahmat, Deni and Gondokesumo, Marisca Evalina and Harjanti, Mathelda Weni and Widowati, Wahyu and Zahiroh, Fadhilah Haifa and Saufa, Zahra Qisthi and Takasenserang, Oktaviana and Hadiprasetyo, Dhanar Septyawan (2025) The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells. HAYATI: Journal of Biosciences, 32 (3). pp. 623-631. ISSN 1978-3019; e-ISSN: 2086-4094

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Abstract

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.

Item Type:	Article
Uncontrolled Keywords:	Antiaging serum, Fibroblast cells, Gene expression, Plant Extract, Salmon DNA
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Ester Sri W. 196039
Date Deposited:	30 Jan 2026 09:11
Last Modified:	30 Jan 2026 09:11
URI:	http://repository.ubaya.ac.id/id/eprint/50223

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