Prediction of Salmon Inhibitor Peptides For DPP-IV Proteins Using Molecular Docking

Saputri, Nahdiyah Vernanda and Antonius, Yulanda (2026) Prediction of Salmon Inhibitor Peptides For DPP-IV Proteins Using Molecular Docking. Jurnal Biologi Tropis, 26 (1). pp. 191-197. ISSN 1411-9587

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Abstract

Diabetes mellitus is the 3rd leading cause of death in Indonesia. Glucagon like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) are incretin hormones that function in postpandrial insulin secretion. The purpose of this study was to determine potential peptides from salmon as DPP-IV inhibitors for antidiabetic drugs, using the molecular docking method. This study design refers to several in silico peptide design studies through a bioinformatics approach. The results showed that bioactivepeptide molecules derived from salmon, as well as peptide 1 and peptide 2 were predicted as potential molecular peptides and had good interactions with DPP-IV proteins, and were proven to be able to inhibit the DPP-IV enzyme as a target for diabetes mellitus drugs through the identification and evaluation of molecular interactions that occurred using the in silico peptide protein-based molecular binding method. The conclusion is that bioactive peptide molecules derived from salmon, as well as peptide 1 andpeptide 2 were predicted as potential molecular peptides and had good interactions with DPP-IV proteins and were proven to be able to inhibit the DPP-IV enzyme.

Item Type:	Article
Uncontrolled Keywords:	Diabetes Melitus, DPP-IV, Molecular Docking, Peptide
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	BAMBANG SEPTIAWAN
Date Deposited:	20 Feb 2026 02:51
Last Modified:	20 Feb 2026 02:51
URI:	http://repository.ubaya.ac.id/id/eprint/50345

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