Flavonoid Microparticles from Herbal Extracts: Advances in Formulation, Characterisation and Therapeutic Potential

Afifah, Liya Izzati Diana and Setiawan, Finna and Pradana, Aditya Trias and Wungsintaweekul, Boonsong and Kartini, Kartini (2026) Flavonoid Microparticles from Herbal Extracts: Advances in Formulation, Characterisation and Therapeutic Potential. Journal of Applied Pharmaceutical Science, 16 (7). pp. 244-258. ISSN 2231-3354

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Abstract

Flavonoids are bioactive plant secondary metabolites with various pharmacological activities. However, their application is limited by poor solubility, low bioavailability and instability under environmental conditions. Microparticle technology has emerged as a promising approach to overcome these limitations by enhancing flavonoid stability, solubility and controlled release. This narrative review summarises recent advances in the formulation and characterisation of herbal-based flavonoid microparticles, highlighting polymer selection, encapsulation techniques (e.g., solvent evaporation, ionotropic gelation, spray drying, freeze drying and spray chilling), physicochemical properties, and biological activities. The review emphasises that microparticle-based delivery systems may enhance flavonoid bioavailability and preserve bioactivity, offering a potential strategy for the development of novel therapeutic agents. These insights provide a comprehensive reference for future research on the pharmaceutical application of flavonoid microparticles.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Kartini
Date Deposited:	27 Jul 2026 03:48
Last Modified:	27 Jul 2026 03:48
URI:	http://repository.ubaya.ac.id/id/eprint/51014

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