Bacterial Lipoxygenases: Versatile Biocatalysts for Fatty Acid Oxyfunctionalization

Chrisnasari, Ruth Bacterial Lipoxygenases: Versatile Biocatalysts for Fatty Acid Oxyfunctionalization. In: The 2nd MU–UBAYA Joint Symposium, 25 May 2026, Online. (Unpublished)

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Abstract

Abstract: The shift to a biobased economy aims to reduce dependence on fossil fuels by converting biological materials, such as plant- and algae-derived fatty acids, into valuable compounds. The enzymatic oxyfunctionalization of fatty acids is of special interest because it enables the eco-friendly synthesis of a wide range of products with unique properties. Lipoxygenases (LOXs) are key oxyfunctionalization enzymes featuring broad substrate specificities and distinct regioselectivities. Among them, bacterial LOXs remain underexplored compared to their eukaryotic counterparts, representing an untapped resource with unique structural and functional traits. Our studies highlight recent advances in bacterial LOXs, emphasizing their versatile oxidative capabilities via dioxygenase and hydroperoxide isomerase activities. Key strategies, including protein engineering and oxygen level modulation, are discussed for modifying substrate specificity, regioselectivity, and preferred catalytic pathway. Multi-enzyme cascade reactions further expand the scope of LOX-derived products, unlocking new applications in biotechnological contexts. We address challenges in harnessing bacterial LOXs’ biocatalytic potential and propose solutions to optimize their performance. Our works enhance understanding of bacterial LOXs and highlight their potential for transformative biotechnological applications in fatty acid derivatization. Keywords: dioxygenase, hydroperoxide isomerase, lipoxygenase, oxyfunctionalization, oleochemicals, oxidoreductase, oxylipins

Item Type:	Conference or Workshop Item (Keynote)
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	RUTH CHRISNASARI - 210001
Date Deposited:	06 Aug 2026 07:15
Last Modified:	06 Aug 2026 07:15
URI:	http://repository.ubaya.ac.id/id/eprint/51136

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