Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract

Sukweenadhi, Johan and Chandra, Stefan Pratama and Setiawan, Finna and Avanti, Christina and Kartini, Kartini and Koeswanto, Arief and Yang, Deok-Chun (2023) Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract. Sarhad Journal of Agriculture, 39 (1). pp. 11-22. ISSN 1016-4383; E-ISSN 2224-5383

PDF [Combined] Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract.pdf - Published Version Restricted to Registered users only Download (18MB) | Request a copy

Abstract

Skin is the largest organ in the body and has a very important role. A wound is an injury in which the skin is torn, cut, punctured, or traumatized. Wounds in diabetic patients are difficult to heal. Green synthesis is one of many methods that can be used to synthesize silver nanoparticles. Based on a statistical analysis of the average wound area, epidermal reconstruction, and TIME-H scores, significant differences began to occur from day 12 to day 14. The average wound area, epidermal reconstruction, and TIME-H scores in the diabetic mice group that were given a dermal patch formulated with silver nanoparticles synthesized using Plantago major L. extract were not significantly different from the normal group and the ACA and ACA Ag groups. Based on these results, it can be concluded that the dermal patch formulated with silver nanoparticles synthesized using Plantago major L. extract helps wound healing in diabetic mice and is not significantly different from wound dressings and silver dressings on the market (p-value < 0.05). In addition, the best concentration that can be formulated into the dermal patch is 0.005% (p-value <0.05).

Item Type:	Article
Uncontrolled Keywords:	Diabetic mice, Silver nanoparticles, Plantago major L., Wound area
Subjects:	Q Science > QK Botany R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology S Agriculture > S Agriculture (General) S Agriculture > SB Plant culture T Technology > TP Chemical technology
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	JOHAN SUKWEENADHI
Date Deposited:	08 Jan 2024 03:51
Last Modified:	13 Feb 2024 08:30
URI:	http://repository.ubaya.ac.id/id/eprint/45624

Actions (login required)

View Item