Nasal Delivery of Asiatic Acid AmelioratesScopolamine-Induced Memory Dysfunction in Mice

Myint, Su Lwin Lwin and Rodsiri, Ratchanee and Benya-aphikul, Hattaya and Rojanaratha, Tissana and Ritthidej, Garnpimol and Islamie, Ridho (2024) Nasal Delivery of Asiatic Acid AmelioratesScopolamine-Induced Memory Dysfunction in Mice. Advances in Pharmacological and Pharmaceutical Sciences, 2024 (1). pp. 1-8. ISSN 2633-4690

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Abstract

Asiatic acid (AA) has previously shown its neuroprotective effects, but low oral bioavailability limits its penetration into the brain. +is study aimed to investigate the effect of intranasal AA administration in mice with memory dysfunction induced by scopolamine. Mice received either intranasal AA (INAA), oral AA (POAA3 or POAA30), or donepezil, followed by scopolamine for 10 days. Morris water maze (MWM) was performed on days 0–5, 30 min after treatment. Locomotor activity was conducted on day 6 followed by brain collection. In MWM, INAA treatment had signi8cantly reduced escape latency on days 2–4, while POAA3 decreased escape latency on day 3 and POAA30 and donepezil decreased escape latency on day 4. INAA inhibited acetylcholinesterase activity, increased catalase protein expression, and decreased malondialdehyde levels in the brain tissue. therefore, intranasal administration of AA produced a rapid onset in the protection of learning and memory de8cits induced by scopolamine through acetylcholinesterase inhibition and antioxidant effect.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Pharmacy > Department of Pharmacy
Depositing User:	Eko Setiawan 194014
Date Deposited:	08 Oct 2024 05:04
Last Modified:	10 Oct 2024 09:01
URI:	http://repository.ubaya.ac.id/id/eprint/47208

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