A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications

Haribalan, Perumalsamy and Balusamy, Sri Renukadevi and Sukweenadhi, Johan and Nag, Sagnik and MubarakAli, Davoodbasha and Farh, Mohamed El‑Agamy and Shadi, Rahimi (2024) A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications. Journal of Nanobiotechnology, 22 (1). pp. 1-27. ISSN 1477-3155

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Abstract

Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis of a vast majority of metal nanoparticles (NPs). The diverse secondary metabolites present in this plant turn it into a green tool for synthesis of different NPs with various biological activities. In this review, we discussed different types of NPs including silver, gold, titanium oxide, iron oxide, and zinc oxide NPs produced from the extract of different parts of M. oleifera. Different parts of M. oleifera take a role as the reducing, stabilizing, capping agent, and depending on the source of extract, the color of solution changes within NP synthesis. We highlighted the role of polyphenols in the synthesis of NPs among major constituents of M. oleifera extract. The different synthesis methods that could lead to the formation of various sizes and shapes of NPs and play crucial role in biomedical application were criti cally discussed. We further debated the mechanism of interaction of NPs with various sizes and shapes with the cells, and further their clearance from the body. The application of NPs made from M. oleifera extract as anticancer, antimi crobial, wound healing, and water treatment agent were also discussed. Small NPs show better antimicrobial activ ity, while they can be easily cleared from the body through the kidney. In contrast, large NPs are taken by the mono nuclear phagocyte system (MPS) cells. In case of shape, the NPs with spherical shape penetrate into the bacteria, and show stronger antibacterial activity compared to the NPs with other shapes. Finally, this review aims to correlate the key characteristics of NPs made from M. oleifera extract, such as size and shape, to their interactions with the cells for designing and engineering them for bio‑applications and especially for therapeutic purposes.

Item Type:	Article
Uncontrolled Keywords:	Moringa nanoparticles, Metal nanoparticles, Green synthesis, Secondary metabolites, Application of Moringa nanoparticles, Critical parameters
Subjects:	Q Science > QD Chemistry Q Science > QK Botany R Medicine > RS Pharmacy and materia medica S Agriculture > S Agriculture (General)
Divisions:	Faculty of Technobiology > Department of Biology
Depositing User:	JOHAN SUKWEENADHI
Date Deposited:	13 Mar 2025 03:30
Last Modified:	13 Mar 2025 03:30
URI:	http://repository.ubaya.ac.id/id/eprint/48174

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